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It is well known as a high-tech centre in the vicinity of Frankfurt Airport, with important activities in spacecraft operations (the European Space Operations Centre, European Organisation for the Exploitation of Meteorological Satellites), chemistry, pharmacy, information technology, biotechnology, telecommunications (substantial Deutsche Telekom presence) and mechatronics.In 2000, its region also scored Rank 3 amongst 97 German regions in the Wirtschafts Woche test ranking Germany's high-tech regions.As the capital of an increasingly prosperous duchy, the city gained some international prominence and remains one of the wealthiest cities in Europe.In the 20th century, industry (especially chemicals), as well as large science and electronics (later information technology) sectors became increasingly important, and are still a major part of the city's economy.Darmstadt was selected as the secondary target for the raid, but was promoted to the primary target after clouds were observed over the primary which would have hindered any reconnaissance of the after-effects.During this fire attack an estimated 11,000 to 12,500 of the inhabitants burned to death, and 66,000 to 70,000 were left homeless.Annual architectural competitions led to the building of many architectural treasures of this period.Also during this period, in 1912 the chemist Anton Kollisch, working for the pharmaceutical company Merck, first synthesised the chemical MDMA (ecstasy) in Darmstadt.
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) as it is a major centre of scientific institutions, universities, and high-technology companies.
The European Space Operations Centre (ESOC) is located in Darmstadt, as well as GSI Centre for Heavy Ion Research, where several chemical elements such as bohrium (1981), meitnerium (1982), hassium (1984), darmstadtium (1994), roentgenium (1994), and copernicium (1996) were discovered.
The shops were only closed for one day, for "endangering communal order and tranquility". Several prominent members of the German resistance movement against the Nazis were citizens of Darmstadt, including Wilhelm Leuschner and Theodor Haubach, both executed for their opposition to Hitler's regime.
Allied bombing destroyed 70% of the built up area of the city during World War II.